性腺决定的遗传学

Genetic of gonadal determination.

作者信息

Morel Yves, Roucher Florence, Mallet Delphine, Plotton Ingrid

机构信息

Service d'hormonologie, d'endocrinologie moléculaire et des maladies rares, centre de biologie et pathologie Est, université Lyon 1, groupement hospitalier Est- HCL, 59, boulevard Pinel, 69677 Bron cedex, France.

出版信息

Ann Endocrinol (Paris). 2014 May;75(2):32-9. doi: 10.1016/j.ando.2014.04.005. Epub 2014 Apr 29.

DOI:10.1016/j.ando.2014.04.005

PMID:24793987

Abstract

Fetal sexual differentiation results from complex subsequent intracellular signaling and hormonal events that interact together in a definite timing. This process contributes to the setting of gonad determination, internal and external genitalia resulting in a female or male phenotype. Here, we review our current knowledge of gonadal determination drawing on insights from knock-out and transgenic mouse models and analysis of patients with disorders of sex development (DSD).

摘要

胎儿性别分化源于复杂的后续细胞内信号传导和激素事件，这些事件在特定时间相互作用。这一过程有助于性腺决定、内外生殖器的发育，从而形成女性或男性表型。在此，我们借鉴基因敲除和转基因小鼠模型的研究成果以及对性发育障碍（DSD）患者的分析，综述我们目前对性腺决定的认识。