Morel Yves, Roucher Florence, Mallet Delphine, Plotton Ingrid
Service d'hormonologie, d'endocrinologie moléculaire et des maladies rares, centre de biologie et pathologie Est, université Lyon 1, groupement hospitalier Est- HCL, 59, boulevard Pinel, 69677 Bron cedex, France.
Service d'hormonologie, d'endocrinologie moléculaire et des maladies rares, centre de biologie et pathologie Est, université Lyon 1, groupement hospitalier Est- HCL, 59, boulevard Pinel, 69677 Bron cedex, France.
Ann Endocrinol (Paris). 2014 May;75(2):32-9. doi: 10.1016/j.ando.2014.04.005. Epub 2014 Apr 29.
Fetal sexual differentiation results from complex subsequent intracellular signaling and hormonal events that interact together in a definite timing. This process contributes to the setting of gonad determination, internal and external genitalia resulting in a female or male phenotype. Here, we review our current knowledge of gonadal determination drawing on insights from knock-out and transgenic mouse models and analysis of patients with disorders of sex development (DSD).
胎儿性别分化源于复杂的后续细胞内信号传导和激素事件，这些事件在特定时间相互作用。这一过程有助于性腺决定、内外生殖器的发育，从而形成女性或男性表型。在此，我们借鉴基因敲除和转基因小鼠模型的研究成果以及对性发育障碍（DSD）患者的分析，综述我们目前对性腺决定的认识。
