Department of Psychiatry, WuZhongpei Memorial Hospital, No. 3 Jianmin Road, Daliang Town, Shunde District of Foshan City, Guangdong 528300, China.
Department of Psychiatry, WuZhongpei Memorial Hospital, No. 3 Jianmin Road, Daliang Town, Shunde District of Foshan City, Guangdong 528300, China.
Psychiatry Res. 2014 Aug 15;218(1-2):75-8. doi: 10.1016/j.psychres.2014.04.029. Epub 2014 Apr 18.
This study investigated medication compliance, disease recurrence and the recovery of social function in discharged psychiatric patients with bipolar disorder. A 2-year follow-up was conducted on all patients with bipolar disorder, who were hospitalized in our psychiatric department between June 2010 and May 2011. Risk factors for recurrence were analyzed based on a self-designed questionnaire. Of the 252 patients in the study, 210 had complete information (83.3%) for the 2-year follow-up: 170 cases of bipolar I disorder and 40 cases of bipolar II disorder. The 1-year and 2-year full-compliance rates were 41.0% and 35.7%, respectively. The 1-year and 2-year recurrence rates were 42.4% and 61.0%, respectively. Statistically significant differences in rates were found between the bipolar subtypes for 1-year full compliance, 1-year non-compliance, 2-year recurrence, and 2-year readmission. Logistic regression identified different sets of independent variables that were risk factors for recurrence, and protective factors for recurrence at 1 year and 2 years after hospital discharge. The results of the follow-up indicated that the situation of patients with bipolar disorder after discharge is not optimistic, because of high recurrence rates, high non-compliance rates and low recovery rates. Clinical and social experts should pay more attention to the situation.
本研究旨在调查双相情感障碍出院患者的用药依从性、疾病复发和社会功能恢复情况。对 2010 年 6 月至 2011 年 5 月在我院精神科住院的所有双相情感障碍患者进行了为期 2 年的随访。根据自行设计的问卷分析了复发的危险因素。在 252 名研究患者中，有 210 名患者有完整的 2 年随访信息（83.3%）：170 例双相 I 型障碍和 40 例双相 II 型障碍。1 年和 2 年的完全依从率分别为 41.0%和 35.7%。1 年和 2 年的复发率分别为 42.4%和 61.0%。双相亚型之间在 1 年完全依从、1 年不依从、2 年复发和 2 年再入院率方面存在显著差异。Logistic 回归确定了不同的独立变量集，这些变量是复发的危险因素，也是 1 年和 2 年后出院复发的保护因素。随访结果表明，双相情感障碍患者出院后的情况不容乐观，因为复发率高、不依从率高、恢复率低。临床和社会专家应更加关注这种情况。
