Frolkis V V, Nikolaev V G, Paramonova G I, Shchorbitskaya E V, Bogatskaya L N, Stupina A S, Kovtun A I, Sabko V E, Shaposhnikov V M, Muradian K K
Institute of Gerontology AMS USSR.
Biomater Artif Cells Artif Organs. 1989;17(3):341-51. doi: 10.3109/10731198909118290.
Experiments were performed on Wistar male rats, starting from the 28th month of age. The effect of dietary sorbent (non coated nitrogen-containing carbon administered as 10 day courses at 1 month intervals in dosage of 10 ml/kg) on lifespan and a number of biological indices were studied. Enterosorption resulted in the increase of mean and maximal lifespan by 43 and 34% respectively. Analysis of the effect of enterosorption on activity of microsomal enzymes, intensity of total RNA and protein biosynthesis, lipid metabolism, formation of free radicals etc. showed that it produced a positive influence on the functional state of the studied systems and increased the organism's adaptive capacities. Enterosorption was found to delay the rate of onset of age-related structural changes in the organs and tissues.
实验以28月龄的雄性Wistar大鼠为对象开展。研究了膳食吸附剂（未包衣的含氮碳，每隔1个月服用10天，剂量为10毫升/千克）对寿命及多项生物学指标的影响。肠道吸附分别使平均寿命和最大寿命提高了43%和34%。对肠道吸附对微粒体酶活性、总RNA和蛋白质生物合成强度、脂质代谢、自由基形成等方面影响的分析表明，其对所研究系统的功能状态产生了积极影响，并提高了机体的适应能力。研究发现肠道吸附延缓了器官和组织中与年龄相关的结构变化的发生速度。
