Towle V L, Maselli R, Bernstein L P, Spire J P
Department of Neurology, University of Chicago, IL 60637.
Electroencephalogr Clin Neurophysiol. 1989 Nov;73(5):419-26. doi: 10.1016/0013-4694(89)90091-6.
Somatosensory evoked potentials, brain-stem auditory evoked potentials and electroencephalograms were obtained from 9 patients with the diagnosis of 'locked-in' syndrome. No pattern of evoked potential abnormality was specific to this syndrome, with findings ranging from bilaterally normal to unilaterally or bilaterally absent. The evoked potential studies complemented radiographic findings in defining the extent of the lesion and revealed that a portion of the pontine tegmentum was usually involved. Pathology from 2 patients corroborated the findings of the evoked potential studies. The value of evoked potential studies of patients with locked-in syndrome is to provide early objective evidence of brain-stem involvement independent of the clinical examination, EEG and radiographic studies.
对9例诊断为“闭锁综合征”的患者进行了体感诱发电位、脑干听觉诱发电位和脑电图检查。没有一种诱发电位异常模式是该综合征所特有的，其结果从双侧正常到单侧或双侧缺失不等。诱发电位研究在确定病变范围方面补充了影像学检查结果，并显示脑桥被盖的一部分通常受累。2例患者的病理学检查证实了诱发电位研究的结果。对闭锁综合征患者进行诱发电位研究的价值在于，能够独立于临床检查、脑电图和影像学检查，提供脑干受累的早期客观证据。
