[抗变应原成分单克隆抗体的制备与特性鉴定]
[Production and characterization of monoclonal antibodies against allergen components].
作者信息
Petersen A, Kahlert H, Jelke H, Becker W M, Schlaak M
机构信息
Forschungsinstitut Borstel, Medizinsche Klinik, Laborgruppe Allergologie.
出版信息
Immun Infekt. 1989 Oct;17(5):158-64.
Monoclonal antibodies are useful tools for characterizing components causing type I allergy. Three aspects in production and characterization of monoclonal antibodies are discussed: 1. production of monoclonal antibodies raised against a special allergen of rye pollen extract. 2. investigation of monoclonal antibodies raised against peptide fragments of ovalbumin, 3. analysis of epitopes on allergenic components of timothy pollen extracts. The results indicate that monoclonal antibodies raised against certain allergens are useful for isolation of allergenic components and epitope mapping.
单克隆抗体是用于鉴定引发I型过敏的成分的有用工具。本文讨论了单克隆抗体生产与鉴定中的三个方面：1. 针对黑麦花粉提取物的特定过敏原产生的单克隆抗体。2. 针对卵清蛋白肽片段产生的单克隆抗体的研究。3. 梯牧草花粉提取物过敏原成分上的表位分析。结果表明，针对某些过敏原产生的单克隆抗体可用于过敏原成分的分离和表位图谱分析。
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