Jiang Duo-Sheng, Wu Xian-Qun, Zhang Ying-Chun
Zhongguo Zhen Jiu. 2014 Feb;34(2):130-4.
To explore the effects of warm needling combined with Zhangmo decoction (see text) on endometrial receptivity in patients with clomiphene (CC)-induced ovulation.
One hundred and sixty cases were randomly divided into a CC group (group A), a CC+ progynova group (group B), a CC+ Zhangmo decoction group (group C) and a CC+ Zhangmo decoction + warm needling group (group D), 40 cases in each one. In the Group A, CC alone was applied. In the group B, progynova was jointly used on the 8th day of menstrual cycle. In the Group C, Zhangmo decoction was jointly used on the 5th day of menstrual cycle. In the group D, based on treatment of the Zhangmo decoction, warm needling was applied at Guanyuan (CV 4), Zhongji (CV 3) and Zigong (EX-CA 1) etc. The endometrial thickness and type, pulsatility index (PI), resistance index (RI), ratio of S/D on day of human chorionic gonadotropin (HCG) and pregnancy rate were observed in fou groups.
The PI, RI and S/D in the group C and D were obviously lower than those in group A and B (all P < 0.01). The endometrial thickness was (7.7 +/- 1.49) mm in group B, (8.2 +/- 1.54) mm in group C and (8.9 +/- 1.51) mm in group D, which were significantly different from (6.4 5 +/- 1.26) mm in the group A (all P < 0.01) also there was a significant difference between group C and D (P < 0.05). The rate of endometrial type A was 65.0% in the group D, which was significantly higer than 27.5% in the group A, 32.5% in the group B and 35.0% in the group C (all P < 0.01). The pregnancy rate was 30.0% in the group D, which was obviously higher than 12.5% in the group A, 15.0% in the group B and 17.5% in the group C (P < 0.05). The endometrial thickness and rate of endometrial type A in the pregnant were obviously higher than those in the non-pregnant (both P < 0.01) while PI, RI and S/D was lower than those in the non-pregnant (P < 0.01, P < 0.05).
Warm needing combined with Zhangmo decoction could improve endometrial thickness, morphology and uterine spiral artery to improve pregnancy rate, which has superior effect to clomiphene, clomiphene combined with progynova and clomiphene combined with Zhangmo decoction.
探讨温针联合张摩汤（见原文）对克罗米芬（CC）促排卵患者子宫内膜容受性的影响。
将160例患者随机分为CC组（A组）、CC+补佳乐组（B组）、CC+张摩汤组（C组）和CC+张摩汤+温针组（D组），每组40例。A组单纯应用CC；B组在月经周期第8天联合应用补佳乐；C组在月经周期第5天联合应用张摩汤；D组在张摩汤治疗基础上，于关元（CV4）、中极（CV3）、子宫（EX-CA1）等穴位行温针治疗。观察四组患者人绒毛膜促性腺激素（HCG）日的子宫内膜厚度、类型、搏动指数（PI）、阻力指数（RI）、S/D比值及妊娠率。
C组和D组的PI、RI及S/D均明显低于A组和B组（均P<0.01）。B组子宫内膜厚度为（7.7±1.49）mm，C组为（8.2±1.54）mm，D组为（8.9±1.51）mm，均与A组的（6.45±1.26）mm有显著差异（均P<0.01），且C组与D组之间也有显著差异（P<0.05）。D组A型子宫内膜率为65.0%，明显高于A组的27.5%、B组的32.5%和C组的35.0%（均P<0.01）。D组妊娠率为30.0%，明显高于A组的12.5%、B组的15.0%和C组的17.5%（P<0.05）。妊娠患者的子宫内膜厚度和A型子宫内膜率明显高于未妊娠患者（均P<0.01），而PI、RI及S/D低于未妊娠患者（P<0.01，P<0.05）。
温针联合张摩汤可改善子宫内膜厚度、形态及子宫螺旋动脉情况，提高妊娠率，其效果优于克罗米芬、克罗米芬联合补佳乐及克罗米芬联合张摩汤。
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