Kadjane Pascal, Platas-Iglesias Carlos, Boehm-Sturm Philipp, Truffault Vincent, Hagberg Gisela E, Hoehn Mathias, Logothetis Nikos K, Angelovski Goran
Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 Tübingen (Germany).
Chemistry. 2014 Jun 10;20(24):7351-62. doi: 10.1002/chem.201400159. Epub 2014 May 5.
Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set of dual-frequency calcium-responsive MRI agents are reported. These are paramagnetic, fluorine-containing complexes that produce remarkably high MRI signal changes at the (1)H and (19)F frequencies at varying Ca(2+) concentrations. The nature of the processes triggered by Ca(2+) was revealed, allowing a better understanding of these complex systems and their further improvement. The findings indicate that these double-frequency tracers hold great promise for development of novel functional MRI methods.
响应性或智能磁共振成像（MRI）造影剂是分子传感器，其在微环境中特定参数发生变化时会改变MRI信号。因此，它们可用于可视化在分子和细胞水平发生的各种生化事件。在本研究中，报道了一组双频钙响应性MRI造影剂。这些是顺磁性含氟配合物，在不同Ca(2+)浓度下，在(1)H和(19)F频率处产生显著高的MRI信号变化。揭示了由Ca(2+)触发的过程的性质，有助于更好地理解这些复杂系统并对其进一步改进。研究结果表明，这些双频示踪剂在新型功能MRI方法的开发方面具有巨大潜力。
