Parekh Nikita, Thomas Joice, John Jubi, Kusurkar Radhika, De Borggraeve Wim M, Dehaen Wim
Molecular Design and Synthesis, Department of Chemistry, KU Leuven , Celestijnenlaan 200F, 3001 Leuven, Belgium.
J Org Chem. 2014 Jun 6;79(11):5338-44. doi: 10.1021/jo5005795. Epub 2014 May 19.
A new class of pyrazolo[3,4-c]pyridine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was synthesized via a Michael addition and reductive cyclization strategy. These fused heterocycles were accessed from simple starting materials such as nitroolefins and 3-ethoxycarbonyl(methylene)pyrazoline-5-one. The pyrazolo-fused heterocycles were obtained in good overall yields.
通过迈克尔加成和还原环化策略合成了一类新型的吡唑并[3,4-c]吡啶-3,7-二酮和吡唑并[3,4-d]氮杂卓-3,7-二酮骨架。这些稠合杂环可由硝基烯烃和3-乙氧基羰基（亚甲基）吡唑啉-5-酮等简单起始原料制得。吡唑稠合杂环的总收率良好。
