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A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

作者信息

Miyasaka T, Tanaka H, Baba M, Hayakawa H, Walker R T, Balzarini J, De Clercq E

机构信息

School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.

出版信息

J Med Chem. 1989 Dec;32(12):2507-9. doi: 10.1021/jm00132a002.

DOI:10.1021/jm00132a002
PMID:2479745
Abstract
摘要

相似文献

1
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.一种新型特异性抗HIV-1药物先导物：1-[(2-羟基乙氧基)甲基]-6-(苯硫基)胸腺嘧啶。
J Med Chem. 1989 Dec;32(12):2507-9. doi: 10.1021/jm00132a002.
2
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.1-[(2-羟乙氧基)甲基]-6-(苯硫基)胸腺嘧啶类似物的构效关系：C-6苯环和C-5位取代对抗HIV-1活性的影响
J Med Chem. 1992 Jan 24;35(2):337-45. doi: 10.1021/jm00080a020.
3
Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.无法磷酸化的特异性抗HIV-1“无环核苷”：1-[(2-羟基乙氧基)甲基]-6-(苯硫基)胸腺嘧啶的一些脱氧类似物的合成
J Med Chem. 1991 Apr;34(4):1508-11. doi: 10.1021/jm00108a041.
4
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
J Med Chem. 1991 Apr;34(4):1394-9. doi: 10.1021/jm00108a023.
5
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.1-[(2-羟基乙氧基)甲基]-6-(苯硫基)胸腺嘧啶（HEPT）的脱氧类似物作为强效和选择性抗HIV-1药物的合成及抗病毒活性
J Med Chem. 1992 Dec 11;35(25):4713-9. doi: 10.1021/jm00103a009.
6
Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.2',3'-双脱氧核苷5'-三磷酸、四氢咪唑并-[4,5,1-jk][1,4]-苯并二氮杂卓-2(1H)-硫酮和1-[(2-羟基乙氧基)甲基]-6-(苯硫基)胸腺嘧啶衍生物对人内源性1型免疫缺陷病毒逆转录的抑制动力学
J Biol Chem. 1992 Jun 15;267(17):11769-76.
7
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.对1-[(2-羟乙氧基)甲基]-6-(苯硫基)胸腺嘧啶衍生物的耐药性是由HIV-1逆转录酶多个位点的突变产生的。
Virology. 1995 Jun 20;210(1):186-93. doi: 10.1006/viro.1995.1330.
8
A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
J Med Chem. 1991 Jan;34(1):349-57. doi: 10.1021/jm00105a055.
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A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.一类新型吡啶酮衍生物作为有效的非核苷类1型人类免疫缺陷病毒特异性逆转录酶抑制剂。
J Med Chem. 1995 Nov 10;38(23):4679-86. doi: 10.1021/jm00023a007.
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Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase.5-乙基-6-苯基硫脲衍生物通过与HIV-1逆转录酶相互作用对1型人类免疫缺陷病毒（HIV-1）产生强效且选择性抑制作用。
Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2356-60. doi: 10.1073/pnas.88.6.2356.

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