小脑桥脑角神经鞘瘤切除术后无缝合纤维蛋白胶辅助面神经移植:技术及15例结果
Stitchless fibrin glue-aided facial nerve grafting after cerebellopontine angle schwannoma removal: technique and results in 15 cases.
作者信息
Ramos Danielle Seabra, Bonnard Damien, Franco-Vidal Valérie, Liguoro Dominique, Darrouzet Vincent
机构信息
*Department of Otolaryngology, Agamenon Magalhães Hospital, Recife, Pernambuco, Brazil; †Department of Otolaryngology and Skull Base Surgery, and ‡Department of Neurosurgery, Pellegrin University Hospital, University Bordeaux Segalen, Bordeaux, France.
出版信息
Otol Neurotol. 2015 Mar;36(3):498-502. doi: 10.1097/MAO.0000000000000408.
AIM OF THE STUDY
To evaluate the results of facial nerve (FN) grafting using great auricular cable graft and fibrin glue without suturing to palliate FN disruption after removal of large cerebellopontine angle (CPA) vestibular schwannoma (VS) or facial nerve schwannoma (FNS). To assess whether tumor size and origin influenced the results.
STUDY DESIGN AND SETTING
Retrospective review of all patients having undergone removal of FNS/VS and needing intraoperative FN repair between 2001 and 2011.
INTERVENTION
FN was rehabilitated using great auricular nerve cable graft and fibrin glue (Tisseal) without stitching suture.
MAIN OUTCOME MEASURES
All data recorded were reviewed to access age, sex, tumor type, and tumor size according to the Koos classification and presenting symptoms. FN function was evaluated preoperatively and at 18 months using the House-Brackmann (HB) grading system.
RESULTS
Among the 595 patients operated for CPA schwannomas in this period, 15 patients (2.5%) underwent FN repair, including 7 cases of FNS and 8 cases of VS. Tumor removal was total in all cases. FN recovery was HB3 in 13 cases (86.7%) and HB4 in 2. The mean time to the first clinical signs of facial reinnervation was 10 months (6-12 mo). No significant relation was found between postoperative facial function and tumor size or type, even if all cases of preoperative FP were noted in FNS.
CONCLUSION
Immediate FN reconstruction with fibrin glue-aided greater auricular nerve graft can effectively restore FN function with excellent outcomes. The results seem better than those observed by other authors using sutured grafts or delayed hypoglossal-facial nerve anastomosis.
研究目的
评估使用耳大神经电缆移植和纤维蛋白胶且不进行缝合来修复面神经(FN),以缓解在切除大型桥小脑角(CPA)前庭神经鞘瘤(VS)或面神经鞘瘤(FNS)后FN损伤的效果。评估肿瘤大小和起源是否会影响结果。
研究设计与背景
对2001年至2011年间所有接受FNS/VS切除且术中需要修复FN的患者进行回顾性研究。
干预措施
使用耳大神经电缆移植和纤维蛋白胶(Tisseal)修复FN,不进行缝合。
主要观察指标
回顾记录的所有数据,以获取年龄、性别、肿瘤类型、根据库斯分类法的肿瘤大小以及呈现的症状。术前和术后18个月使用House-Brackmann(HB)分级系统评估FN功能。
结果
在此期间接受CPA神经鞘瘤手术的595例患者中,15例(2.5%)接受了FN修复,其中7例为FNS,8例为VS。所有病例均实现肿瘤全切。13例(86.7%)患者的FN恢复至HB3级,2例为HB4级。面部再支配的首个临床体征出现的平均时间为10个月(6 - 12个月)。术后面部功能与肿瘤大小或类型之间未发现显著关联,即便所有术前面神经麻痹(FP)病例均见于FNS。
结论
使用纤维蛋白胶辅助耳大神经移植即刻进行FN重建可有效恢复FN功能,效果良好。结果似乎优于其他作者使用缝合移植或延迟舌下 - 面神经吻合术观察到的结果。