无染色体异常且缺乏表面和细胞质免疫球蛋白的伯基特型急性淋巴细胞白血病（L3-ALL）

Acute lymphoblastic leukemia of Burkitt's type (L3-ALL) without chromosome abnormality and lacking surface and cytoplasmic immunoglobulins.

作者信息

Aso T, Hirota Y, Matsumoto I, Kajiyama K, Ohshima K, Kikuchi M

机构信息

Department of Internal Medicine, Matsuyama Red Cross Hospital, Japan.

出版信息

Jpn J Med. 1989 Sep-Oct;28(5):632-5. doi: 10.2169/internalmedicine1962.28.632.

DOI:10.2169/internalmedicine1962.28.632

PMID:2479791

Abstract

A case of heterogeneous acute lymphoblastic leukemia of the Burkitt type (L3-ALL) is reported. A 58-year-old woman was admitted to our hospital with complaints of palpitation and shortness of breath in December 1988. On admission, the peripheral blood showed severe pancytopenia. The bone marrow was hypercellular with abnormal lymphoblasts; the cytoplasm was moderately abundant and intensely basophilic with prominent vacuoles. A diagnosis of L3-ALL was made. Cytogenetic analysis of bone marrow cells revealed a karyotype of 46,XX. The leukemic blasts were HLA-DR+, CD10+, CD19+ and CD20+, but no surface or cytoplasmic immunoglobulins were detected. This is the first report in Japan of a case of L3-ALL without chromosome abnormality and lacking surface and cytoplasmic immunoglobulins.

摘要

报告了一例伯基特型（L3-ALL）异质性急性淋巴细胞白血病病例。一名58岁女性于1988年12月因心悸和呼吸急促入院。入院时，外周血显示严重全血细胞减少。骨髓细胞增多，有异常淋巴母细胞；细胞质中等丰富，嗜碱性强，有明显空泡。诊断为L3-ALL。骨髓细胞的细胞遗传学分析显示核型为46,XX。白血病母细胞HLA-DR+、CD10+、CD19+和CD20+，但未检测到表面或细胞质免疫球蛋白。这是日本首例无染色体异常且缺乏表面和细胞质免疫球蛋白的L3-ALL病例报告。