Barry Conor P, Ahmed Ferhan, Rogers Simon N, Lowe Derek, Bekiroglu Fazilet, Brown James S, Shaw Richard J
Head and Neck Unit, Aintree University Hospital, Liverpool, United Kingdom.
Evidence Based Practice Research Centre (EPRC), Faculty of Health, Edge Hill University, Ormskirk, United Kingdom.
Head Neck. 2015 Aug;37(8):1176-80. doi: 10.1002/hed.23729. Epub 2014 Aug 4.
The purpose of this study was to explore the significance of resection margin status on local recurrence and survival for early (T1/T2) oral cancer and to determine if the significance of the resection margin varies with the biological aggression of the tumor as determined by pN status.
The influence of resection margin size and local recurrence for 295 patients with pT1/T2 oral cavity squamous cell carcinomas (SCCs) treated by primary surgery, including neck dissection, between 1998 and 2010 was analyzed.
Overall, there was a trend toward increased local recurrence with close or involved margins. When stratified according to nodal status, there was no relationship between margin size and local recurrence for the pN0 group.
The size of the resection margin does not seem to influence local control in stage I/II oral cancer. With future advances in preoperative neck staging, this data may help plan personalized therapy in head and neck cancer.
本研究的目的是探讨切缘状态对早期（T1/T2）口腔癌局部复发和生存的意义，并确定切缘的意义是否随由pN状态所确定的肿瘤生物学侵袭性而变化。
分析了1998年至2010年间295例接受包括颈清扫术在内的初次手术治疗的pT1/T2口腔鳞状细胞癌（SCC）患者的切缘大小和局部复发情况。
总体而言，切缘接近或受累时局部复发有增加的趋势。根据淋巴结状态分层时，pN0组的切缘大小与局部复发之间无相关性。
切缘大小似乎不影响I/II期口腔癌的局部控制。随着术前颈部分期技术的未来进展，这些数据可能有助于制定头颈癌的个性化治疗方案。
