Stanfield B B
Laboratory of Clinical Science, National Institute of Mental Health, Poolesville, MD 20837.
Neuroscience. 1989;32(2):381-6. doi: 10.1016/0306-4522(89)90086-9.
Wheat germ agglutinin conjugated to horseradish peroxidase and Fast Blue were used as retrograde tracers to examine the distribution of coeruleohippocampal and coeruleospinal somata within the locus coeruleus of normal and tottering mutant mice. The distributions of these projection neuron populations in normal mice are similar to what has been found in other species, and the distributions of these projection neurons in tottering mice are indistinguishable from those in normal mice, in spite of the norepinephrine hyperinnervation of certain locus coeruleus targets, including the hippocampus, in the tottering mutant. These observations lend support to the notion that the defect in tottering acts fairly directly on mechanisms involved in the development of locus coeruleus axonal arbors within certain target regions.
将与辣根过氧化物酶结合的小麦胚芽凝集素和固蓝用作逆行示踪剂，以检查正常和蹒跚突变小鼠蓝斑内蓝斑-海马和蓝斑-脊髓躯体的分布。这些投射神经元群体在正常小鼠中的分布与在其他物种中发现的相似，并且在蹒跚小鼠中这些投射神经元的分布与正常小鼠中的分布没有区别，尽管在蹒跚突变体中某些蓝斑靶点，包括海马体，存在去甲肾上腺素超神经支配。这些观察结果支持了这样一种观点，即蹒跚突变中的缺陷相当直接地作用于某些靶区域内蓝斑轴突分支发育所涉及的机制。
