Gibson Clare M, Penn David L, Smedley Kelly L, Leserman Jane, Elliott Tonya, Pedersen Cort A
Veterans Affairs Maryland Health Care System, Perry Point VA Medical Center, Perry Point, MD 21902, USA.
Department of Psychology, CB#3270, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Schizophr Res. 2014 Jul;156(2-3):261-5. doi: 10.1016/j.schres.2014.04.009. Epub 2014 May 3.
The current study explored whether oxytocin can improve social cognition and social skills in individuals with schizophrenia using a six-week, double-blind design. Fourteen participants with schizophrenia were randomized to receive either intranasal oxytocin or a placebo solution and completed a battery of social cognitive, social skills and clinical psychiatric symptom measures. Results showed within group improvements in fear recognition, perspective taking, and a reduction in negative symptoms in the oxytocin group. These preliminary findings indicate oxytocin treatment may help improve certain components of functioning in schizophrenia. Implications for the treatment of social functioning in schizophrenia are discussed.
本研究采用为期六周的双盲设计，探讨了催产素是否能改善精神分裂症患者的社会认知和社交技能。14名精神分裂症患者被随机分为两组，分别接受鼻内催产素或安慰剂溶液，并完成了一系列社会认知、社交技能和临床精神症状测量。结果显示，催产素组在恐惧识别、观点采择方面有组内改善，且阴性症状有所减轻。这些初步发现表明，催产素治疗可能有助于改善精神分裂症患者的某些功能组成部分。文中还讨论了催产素对精神分裂症社交功能治疗的意义。
