[通过机械人工心脏瓣膜置换术后患者尿液中氯沙坦及其代谢产物E-3174的含量评估华法林剂量与CYP2C9活性之间的关系]

[Relationship between warfarin dosing and activity of CYP2C9 assessed by the content of losartan and its metabolite E-3174 in the urine of patients with mechanical prosthetic heart valves].

作者信息

Arslanbekova S M, Sychev D A, Kazakov R E, Smirnov V V, Kuznetsova E V, Golukhova E Z

出版信息

Kardiologiia. 2013;53(12):21-4.

Abstract

We evaluated effect of activity of cytochrome P450 CYP2C9 on maintenance doses of warfarin in 33 patients with implanted artificial heart valves. Losartan test was used for measurement of concentration of active metabolite E-3174 in urine. Concentration of E-3174 below 2500 ng/ml in patients with genotype CYP2C981/*1 with sensitivity 87% and specificity 66% predicted requirement of low doses (< 5 mg/day) of warfarin in the late postoperative period (odds ratio 14, 95% confidence interval 1.135 to 172.75).

摘要

我们评估了细胞色素P450 CYP2C9的活性对33例植入人工心脏瓣膜患者华法林维持剂量的影响。使用氯沙坦试验来测量尿液中活性代谢物E-3174的浓度。对于CYP2C9*1/*1基因型患者，E-3174浓度低于2500 ng/ml时，在术后晚期预测低剂量（<5 mg/天）华法林需求的敏感度为87%，特异度为66%（优势比14，95%置信区间1.135至172.75）。