Ono Kenjiro, Yamada Masahito
Rinsho Byori. 2014 Mar;62(3):241-5.
Alpha-Synuclein protein(alphaS) aggregates from a monomer to assemblies such as oligomers, protofibrils, and mature fibrils. The early intermediate aggregate, that is, the oligomer, has been reported to be the most toxic species. We recently reported that melatonin inhibits alphaS aggregation, including protofibril and oligomer formations. While the alphaS concentration in cerebrospinal fluid was reported to significantly decrease in patients with Parkinson's disease (PD) and dementia with Lewy bodies, there have been reports that the alphaS oligomer concentration was elevated in the cerebrospinal fluid of PD patients. Moreover, it was reported that the alphaS oligomer concentration was also elevated in the blood of PD patients. Further studies may establish alphaS in cerebrospinal fluid and blood as a biomarker of alpha-synucleinopathies, including PD.
α-突触核蛋白（αS）从单体聚集成诸如寡聚体、原纤维和成熟纤维等聚集体。据报道，早期中间聚集体，即寡聚体，是毒性最强的物质。我们最近报道褪黑素可抑制αS聚集，包括原纤维和寡聚体的形成。虽然据报道帕金森病（PD）和路易体痴呆患者脑脊液中的αS浓度显著降低，但也有报道称PD患者脑脊液中的αS寡聚体浓度升高。此外，据报道PD患者血液中的αS寡聚体浓度也升高。进一步的研究可能会将脑脊液和血液中的αS确立为包括PD在内的α-突触核蛋白病的生物标志物。
