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[基因组学与个性化医疗]

[Genomics and personalized medicine].

作者信息

Mooser Vincent

机构信息

Département des Laboratoires, CHUV Lausanne.

出版信息

Praxis (Bern 1994). 2014 May 7;103(10):567-71. doi: 10.1024/1661-8157/a001655.

DOI:10.1024/1661-8157/a001655
PMID:24800768
Abstract

Personalized medicine has a substantial potential to transform the way diseases will be predicted, prevented and treated. The field will greatly benefit from novel DNA sequencing technologies, in particular commoditization of individual whole genome sequencing. This evolution cannot be stopped, and the medical and scientific community, as well as the society at large, have the responsibility to anticipate the expected benefits from this revolution, but also the potential risks associated with it. Massive investments will be needed for the potential of personalized medicine to be realized, and for the field to come to maturity. In particular, a paradigm change in the way clinical research is done is needed. Switzerland and its Western part pro-actively anticipate these changes.

摘要

个性化医疗在改变疾病预测、预防和治疗方式方面具有巨大潜力。该领域将从新型DNA测序技术中大大受益,尤其是个人全基因组测序的商品化。这种发展趋势无法阻挡,医学界、科学界以及整个社会都有责任预见这场革命带来的预期益处,同时也要认识到与之相关的潜在风险。要实现个性化医疗的潜力并使其走向成熟,需要大量投资。特别是,临床研究的方式需要发生范式转变。瑞士及其西部地区积极预见到了这些变化。

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