Fridman Wolf H, Sautès-Fridman Catherine
Centre de recherche des Cordeliers, Inserm UMRS 872, 15, rue de l'École de Médecine, 75006 Paris, France - Université Paris-Descartes, Paris, France.
Med Sci (Paris). 2014 Apr;30(4):359-65. doi: 10.1051/medsci/20143004007. Epub 2014 May 5.
Tumors grow surrounded by a complex cellular and tissular microenvironment. Its components influence disease outcome, some accelarating growth and invasion and others blocking it. From the very first steps leading a normal tissue to dysplasia, followed by a benign tumor which may become locally invasive and metastatic, interactions between the transformed cells and their microenvironment direct the evolution of this process. Chronic inflammation in a tissue favors tumor first appearance which then accentuate the nutritional and energetic properties of their microenvironment by producing neoangiogenic, immunosuppressive and inflammatory molecules. In contrast a strong memory Th1/cytotoxic reaction can prevent the transition from benign to malignant tumors and control cancer invasivness and metastasis. Knowledge of these multiple phenomena, discussed in the different articles of the present issue has a major clinical impact, since new prognostic tests and efficient novel therapeutic approaches which target the tumor microenvironment are actively developed.
肿瘤生长于复杂的细胞和组织微环境中。其组成部分会影响疾病的转归，有些会加速肿瘤生长和侵袭，而另一些则会起到抑制作用。从正常组织发展为发育异常，进而形成可能发生局部侵袭和转移的良性肿瘤，这一过程中，转化细胞与其微环境之间的相互作用主导着肿瘤的演变。组织中的慢性炎症有利于肿瘤的初次出现，随后肿瘤通过产生新血管生成、免疫抑制和炎症分子来增强其微环境的营养和能量特性。相反，强烈的记忆性Th1/细胞毒性反应可以阻止肿瘤从良性向恶性转变，并控制癌症的侵袭和转移。本期不同文章中讨论的这些多种现象的相关知识具有重大的临床意义，因为针对肿瘤微环境的新的预后检测方法和有效的新型治疗方法正在积极研发中。
