口腔鳞状细胞癌中17号和18号染色体上乳腺丝氨酸蛋白酶抑制剂（maspin）和p53的杂合性缺失

Loss of heterozygosity in mammary serine protease inhibitor (maspin) and p53 at chromosome 17 and 18 in oral cavity squamous cell carcinoma.

作者信息

Choi Kyu Young, Choi Hyung-Joon, Chung Eun-Jae, Lee Dong Jin, Kim Jin Hwan, Rho Young-Soo

机构信息

Department of Otorhinolaryngology - Head and Neck Surgery, Hallym University College of Medicine, Seoul, Korea.

出版信息

Head Neck. 2015 Sep;37(9):1239-45. doi: 10.1002/hed.23741. Epub 2014 Jul 10.

DOI:10.1002/hed.23741

PMID:24801268

Abstract

BACKGROUND

The purpose of this study was to evaluate the loss of heterozygosity (LOH) in chromosomes 17p13 (p53 gene) and in 18q21 (mammary serine protease inhibitor [maspin] gene), and the expression of both genes in tissues, in patients with oral cavity squamous cell carcinoma (SCC).

METHODS

Thirty patients with oral cavity SCC have been evaluated for the presence of LOH in chromosomes 17p13 and 18q21, and the expression of p53 and maspin in tissues. Clinicopathological features and survival in these patients were also analyzed.

RESULTS

LOH in 17p13 was more frequently identified in patients with lymph node metastasis and/or high TNM classification. LOH in 18q21 was more frequently identified in high primary T classification patients. Increased expression rate of p53 and/or decreased maspin expression rate were significantly higher in oral cavity SCC than normal tissues.

CONCLUSION

LOH on chromosome 17, 18, the expression of p53, and maspin are related to the carcinogenesis of oral cavity SCC. Relationships with clinicopathological factors in oral cavity SCC were also revealed. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1239-1245, 2015.

摘要