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预防性胸大肌肌瓣在放疗后全喉切除术中预防咽瘘的应用

Prophylactic pectoralis major muscle flap in prevention of pharyngocutaneous fistula in total laryngectomy after radiotherapy.

作者信息

Gendreau-Lefèvre Annie-Kim, Audet Nathalie, Maltais Scott, Thuot François

机构信息

Department of Otorhinolaryngology - Head and Neck Surgery, CHU de Québec, Québec, Canada.

出版信息

Head Neck. 2015 Sep;37(9):1233-8. doi: 10.1002/hed.23742. Epub 2014 Jul 24.

Abstract

BACKGROUND

The purpose of this study was to assess the utility of the pectoralis major muscle flap (PMMF) in the prevention of pharyngocutaneous fistula for total laryngectomy after radiotherapy (RT) METHODS: We conducted a retrospective review of 166 patients who underwent a total laryngectomy after RT between 1998 and 2012 at the CHU de Québec.

RESULTS

One hundred fifteen patients underwent a total laryngectomy with primary pharyngeal closure alone and 51 patients received an onlay PMMF. The incidence of pharyngocutaneous fistula in the PMMF group was 14% compared to 36% when only primary closure was done (p = .004). However, the PMMF did not influence the treatment needed for the healing of this complication (p = 1.00). The development of pharyngocutaneous fistula increased the length of stay from 19 to 50 days (p < .0001) and delayed the initiation of oral diet from 15 to 25 days (p = .03).

CONCLUSION

Nonirradiated tissue coverage should be routine in total laryngectomy after RT. PMMF is a good adjunct to prevent pharyngocutaneous fistula.

摘要

背景

本研究的目的是评估胸大肌肌皮瓣(PMMF)在预防放疗(RT)后全喉切除术后咽瘘方面的效用。方法:我们对1998年至2012年期间在魁北克大学中心医院接受RT后全喉切除术的166例患者进行了回顾性研究。

结果

115例患者仅行一期咽闭合的全喉切除术,51例患者接受了外置PMMF。PMMF组咽瘘发生率为14%,而仅行一期闭合时为36%(p = 0.004)。然而,PMMF对该并发症愈合所需的治疗没有影响(p = 1.00)。咽瘘的发生使住院时间从19天延长至50天(p < 0.0001),并使开始经口进食的时间从15天延迟至25天(p = 0.03)。

结论

放疗后全喉切除术中非照射组织覆盖应成为常规操作。PMMF是预防咽瘘的良好辅助手段。

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