IEEE Trans Med Imaging. 2014 Sep;33(9):1788-802. doi: 10.1109/TMI.2014.2320602. Epub 2014 Apr 29.
Flow diversion is an emerging endovascular treatment option for cerebral aneurysms. Quantitative assessment of hemodynamic changes induced by flow diversion can aid clinical decision making in the treatment of cerebral aneurysms. In this article, besides summarizing past key research efforts, we propose a novel metric for the angiographic assessment of flow diverter deployments in the treatment of cerebral aneurysms. By analyzing the frequency spectra of signals derived from digital subtraction angiography (DSA) series, the metric aims to quantify the prevalence of frequency components that correspond to the patient-specific heart rate. Indicating the decoupling of aneurysms from healthy blood circulation, our proposed metric could advance clinical guidelines for treatment success prediction. The very promising results of a retrospective feasibility study on 26 DSA series warrant future efforts to study the validity of the proposed metric within a clinical setting.
血流导向装置是一种新兴的治疗颅内动脉瘤的血管内治疗选择。血流导向装置引起的血流动力学变化的定量评估可以辅助颅内动脉瘤治疗的临床决策。在本文中，除了总结过去的关键研究工作外，我们还提出了一种新的度量标准，用于评估血流导向装置在治疗颅内动脉瘤中的血管造影效果。通过分析数字减影血管造影（DSA）系列信号的频谱，该度量旨在量化与患者特定心率相对应的频率分量的出现频率。该指标表明动脉瘤与健康血液循环的解耦，我们提出的度量标准可以推进治疗成功预测的临床指南。对 26 个 DSA 系列进行的回顾性可行性研究的非常有前景的结果，需要进一步努力在临床环境中研究该指标的有效性。
