Reid L
Ciba Found Symp. 1978(54):297-310. doi: 10.1002/9780470720356.ch15.
Hypersecretion of mucus is a feature of several clinical diseases and in some is associated with mucous gland hypertrophy and goblet cell increase. In a variety of species these changes have been produced by irritants, by infection, or by administration of drugs. While the end result may appear the same, differences emerge in the type and amount of glycoprotein secreted and in the amount retained within the cell. Organ culture can be used to ascertain functional activity. The use of animal models has not only established that these environmental changes cause hypertrophy but indicated some of the intracellular events associated with their development. When new types of granules appear within a cell, they appear first at the apex: a flow chart is offered of the way of which individual cells change and hence the population. The nature of glycoprotein elaborated by a secretory cell can change within hours. A Clara or serous cell can develop into a mucus-secreting or goblet cell. The pattern of reversibility is emerging.
黏液分泌过多是几种临床疾病的特征，在某些情况下与黏液腺肥大和杯状细胞增多有关。在多种物种中，这些变化是由刺激物、感染或药物给药引起的。虽然最终结果可能看起来相同，但分泌的糖蛋白的类型和数量以及细胞内保留的数量会出现差异。器官培养可用于确定功能活性。动物模型的使用不仅证实了这些环境变化会导致肥大，还指出了一些与其发展相关的细胞内事件。当细胞内出现新型颗粒时，它们首先出现在顶端：提供了一个流程图，展示了单个细胞以及细胞群体的变化方式。分泌细胞产生的糖蛋白的性质可在数小时内发生变化。克拉拉细胞或浆液细胞可发展为分泌黏液的细胞或杯状细胞。可逆性模式正在显现。
