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[Blockage of a mitochondrial cationic channel by a mitochondrial addressing peptide].

作者信息

Henry J P, Chich J F, Goldschmidt D, Thieffry M

机构信息

Unité de Neurobiologie Physico-Chimique, C.N.R.S., Institut de Biologie Physico-Chimique, Paris.

出版信息

C R Acad Sci III. 1989;309(4):87-92.

PMID:2480176
Abstract

A 13-residue peptide, including the sequence of the amino terminal end of cytochrome c oxidase subunit IV precursor, blocks a cationic channel from mitochondrial membranes. The effect is reversible and voltage-dependent. The blocking properties suggest that the peptide plugs the pore. Furthermore, when the transmembrane potential favours transfer, the peptide appears to be able to cross the channel.

摘要

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