Ahmadpour-Kacho Mousa, Motlagh Alireza Jashni, Rasoulinejad Seyed Ahmad, Jahangir Tahereh, Bijani Ali, Pasha Yadollah Zahed
Non-Communicable Pediatric Diseases Research Center, Department of Pediatrics, Babol University of Medical Sciences, Babol, IR Iran.
Pediatr Int. 2014 Oct;56(5):726-30. doi: 10.1111/ped.12371. Epub 2014 Sep 16.
Several risk factors are attributed to retinopathy of prematurity (ROP). This study was done to determine any association between hyperglycemia and ROP in premature infants.
In a retrospective case-control analysis, all infants with a gestational age (GA) < 34 weeks and a birthweight (BW) < 2000 g admitted and treated in the Neonatal Intensive Care Unit at Amirkola Children's Hospital, Iran, during March 2007-September 2010 were included. Hyperglycemia was defined as a plasma glucose level of >150 mg/dL during the hospital stay. The duration of being hyperglycemic was also recorded. All of these neonates were examined for ROP by a retinologist unaware of group assignment. The difference in the ROP incidence and also the severity of ROP was compared between the hyperglycemic and non-hyperglycemic infants. Matching was done for GA, BW, and also Clinical Risk Index for Babies score. The data were analyzed by t-test, χ(2) -test and logistic regression test and a P < 0.05 was considered significant.
In total, 155 neonates were examined. Seventy (45.2%) of them developed ROP but 85 (54.8%) did not show any evidence of ROP. The frequency of hyperglycemia in patients with ROP was 33 (47.2%), but in those without ROP, hyperglycemia occurred in five (5.9%) (P = 0.0001). The severity of ROP showed no significant differences between the two groups (P = 0.35). The logistic regression for GA and BW showed a significant correlation between hyperglycemia and ROP (P = 0.0001).
Hyperglycemia is an important risk factor for ROP that can be prevented along with other risk factors by accurate supervision.
早产视网膜病变（ROP）有多种危险因素。本研究旨在确定高血糖与早产儿ROP之间是否存在关联。
在一项回顾性病例对照分析中，纳入了2007年3月至2010年9月期间在伊朗阿米科拉儿童医院新生儿重症监护病房收治并接受治疗的所有胎龄（GA）<34周且出生体重（BW）<2000 g的婴儿。高血糖定义为住院期间血浆葡萄糖水平>150 mg/dL。还记录了高血糖持续时间。所有这些新生儿均由一位不知分组情况的视网膜病专家检查是否患有ROP。比较高血糖组和非高血糖组婴儿ROP发病率及ROP严重程度的差异。对GA、BW以及婴儿临床风险指数评分进行匹配。数据采用t检验、χ²检验和逻辑回归检验进行分析，P<0.05被认为具有统计学意义。
总共检查了155例新生儿。其中70例（45.2%）发生了ROP，但85例（54.8%）未显示任何ROP迹象。ROP患者中高血糖的发生率为33例（47.2%），但在无ROP的患者中，高血糖发生在5例（5.9%）（P = 0.0001）。两组之间ROP严重程度无显著差异（P = 0.35）。GA和BW的逻辑回归显示高血糖与ROP之间存在显著相关性（P = 0.0001）。
高血糖是ROP的一个重要危险因素，通过精确监测可与其他危险因素一起预防。
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