早产儿视网膜病变不同阶段、区域及缓解/进展状态的临床参数。

Clinical parameters in different stages, zones, and remission/progression statuses of retinopathy of prematurity.

作者信息

Rasoulinejad Seyed Ahmad, Maroufi Faezeh, Alizadeh Ahad

机构信息

Department of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.

Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.

出版信息

Caspian J Intern Med. 2022 Spring;13(2):385-392. doi: 10.22088/cjim.13.2.10.

DOI:10.22088/cjim.13.2.10

PMID:35919643

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9301226/

Abstract

BACKGROUND

Retinopathy of prematurity (ROP) is a vasoproliferative retinal disease in premature infants that causes lifetime visual impairment and blindness in the early ages. In this study, we investigated the differences in the values of clinical laboratory parameters between different ROP and its remission/progression statuses regarding stages and zones.

METHODS

This historical cohort study includes 828 infants divided into two groups after the first examination containing ROP infants and controls. The biochemical and hematological parameters of the two groups have been collected from the patient's history.

RESULTS

In infants with ROP, the hematopoiesis-related parameters, including the mean level of hemoglobin, total bilirubin, potassium, calcium were significantly less than controls (P=0.039, P=0.001, P=0.001, and P=0.046, respectively). The percentages of reticulocyte and the levels of BUN in ROP patients were significantly higher than in normal infants (P=0.015 and p <0.001, respectively). Moreover, the levels of hemoglobin and BUN were significantly different in the different zones of ROP (P=0.017 and P=0.001, respectively). Also, higher hemoglobin levels, total bilirubin, and CRP were observed in the reduced stages of ROP (P=0.041, P=0.045, and P=0.039, respectively).

CONCLUSION

Laboratory parameters are different in different stages, zones and remission/ progression ROP infants.

摘要

背景

早产儿视网膜病变（ROP）是一种发生于早产儿的视网膜血管增生性疾病，可导致早期终身视力损害和失明。在本研究中，我们调查了不同ROP及其缓解/进展状态在分期和分区方面临床实验室参数值的差异。

方法

这项历史性队列研究纳入了828名婴儿，在首次检查后分为两组，包括ROP婴儿组和对照组。两组的生化和血液学参数均从患者病史中收集。

结果

ROP婴儿的造血相关参数，包括血红蛋白平均水平、总胆红素、钾、钙均显著低于对照组（分别为P = 0.039、P = 0.001、P = 0.001和P = 0.046）。ROP患者的网织红细胞百分比和血尿素氮水平显著高于正常婴儿（分别为P = 0.015和P < 0.001）。此外，ROP不同分区的血红蛋白和血尿素氮水平存在显著差异（分别为P = 0.017和P = 0.001）。而且，在ROP病情减轻阶段观察到较高的血红蛋白水平、总胆红素和CRP（分别为P = 0.041、P = 0.045和P = 0.039）。