Nelson B E, Borden E C
Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison 53792.
Semin Surg Oncol. 1989;5(6):391-401. doi: 10.1002/ssu.2980050605.
Interferons play a key role in the immune system as biological response modifiers. Interferons alpha, beta, and gamma have been characterized, their nucleotide sequences defined, and the proteins produced by recombinant DNA technology. The myriad actions of interferons include enhancement of natural killer cell activity and antigen expression, induction of varied proteins, activation of macrophages, and antiviral, antiproliferative and antitumor effects. Clinical trials have demonstrated efficacy of interferons in some malignancies and ongoing studies are investigating results of combinations with other biological response modifiers and cytotoxic agents.
干扰素作为生物反应调节剂在免疫系统中发挥关键作用。α、β和γ干扰素已得到鉴定，其核苷酸序列已明确，并且已通过重组DNA技术生产出这些蛋白质。干扰素的众多作用包括增强自然杀伤细胞活性和抗原表达、诱导多种蛋白质、激活巨噬细胞以及产生抗病毒、抗增殖和抗肿瘤作用。临床试验已证明干扰素在某些恶性肿瘤中具有疗效，正在进行的研究正在探究其与其他生物反应调节剂和细胞毒性药物联合使用的结果。
