矽肺患者血浆中炎症生物标志物与放射学严重程度和暴露时间的关系。

Association between inflammatory biomarkers in plasma, radiological severity, and duration of exposure in patients with silicosis.

机构信息

From the Programa Multicêntrico de Pós Graduação em Ciências Fisiológicas (Ms Braz and Drs Lacerda and Mendonça), Sociedade Brasileira de Fisiologia; Laboratório de Inflamação e Metabolismo-UFVJM (Ms Braz and Dr Mendonça), Diamantina; State Reference Center in Occupational Health (Dr Carneiro), the Clinics Hospital-UFMG, Belo Horizonte; Department of Physiology (Mr Amorim), School of Medicine of Ribeirão Preto-USP, Ribeirão Preto; Department of Basic Sciences-UFVJM (Dr de Oliveira Ferreira), Diamantina; Laboratório de Imunofarmacologia-ICB/UFMG (Ms Silva de Miranda and Drs M.M. Teixeira and A.L. Teixeira), Belo Horizonte, Brazil.

出版信息

J Occup Environ Med. 2014 May;56(5):493-7. doi: 10.1097/JOM.0000000000000164.

DOI:10.1097/JOM.0000000000000164

PMID:24806562

Abstract

OBJECTIVE

To evaluate the plasma levels of CCL2, CCL3, CCL11, CCL24, tumor necrosis factor alpha, sTNFR1, and sTNFR2 in subjects exposed to silica (SES) with and without silicosis compared with unexposed reference control group, and their associations with the radiological severity and duration of exposure to silica.

METHODS

Fifty-seven SES; 36 with silicosis and 22 subjects in control group, were included in the study.

RESULTS

CCL3, CCL24, sTNFR1, and sTNFR2 were increased in SES and in SES with silicosis than in controls. There were no differences in the levels of CCL2, CCL11, or tumor necrosis factor alpha. The sTNFR2 level was greater in SES with silicosis than in SES without silicosis. There was a positive correlation between sTNFR1 and sTNFR2 and the radiological severity and time of exposure to silica. sTNFR2 was associated with all categories of radiological severity.

CONCLUSION

sTNFR2 is associated with silicosis severity and early exposure to silica.

摘要

目的

评估暴露于二氧化硅（SES）的个体与未暴露于二氧化硅的参考对照组相比，其血浆中 CCL2、CCL3、CCL11、CCL24、肿瘤坏死因子-α、可溶性肿瘤坏死因子受体 1（sTNFR1）和可溶性肿瘤坏死因子受体 2（sTNFR2）的水平，并分析它们与矽肺严重程度和暴露于二氧化硅时间的关系。

方法

本研究共纳入 57 例 SES 患者，其中 36 例患有矽肺，22 例为对照组。

结果

与对照组相比，SES 组和 SES 合并矽肺组的 CCL3、CCL24、sTNFR1 和 sTNFR2 水平均升高。CCL2、CCL11 或肿瘤坏死因子-α水平无差异。与无矽肺的 SES 患者相比，合并矽肺的 SES 患者的 sTNFR2 水平更高。sTNFR1 和 sTNFR2 与矽肺严重程度和暴露于二氧化硅时间呈正相关。sTNFR2 与所有矽肺严重程度类别均相关。