细胞因子和可溶性受体对接触二氧化硅工人生活质量和功能能力的影响。
Influence of Cytokines and Soluble Receptors in the Quality of Life and Functional Capacity of Workers Exposed to Silica.
作者信息
Braz Nayara Felicidade Tomaz, Carneiro Ana Paula Scalia, Avelar Núbia Carelli Pereira de, Miranda Aline Silva de, Lacerda Ana Cristina Rodrigues, Teixeira Mauro Martins, Teixeira Antônio Lúcio, Mendonça Vanessa Amaral
机构信息
Post Graduate Multicenter Program in Physiological Sciences (Dr Braz, Dr Lacerda, Dr Mendonça), Brazilian Society of Physiology, São Paulo; Inflammation and Metabolism Laboratory (Dr Braz, Dr Mendonça), UFVJM, Diamantina; Medical Doctor of State Reference Center in Occupational Health (Dr Carneiro), the Clinics Hospital, UFMG, Belo Horizonte; Department of Physical Therapy (Dr de Avelar), UFSC, Araranguá; Immunopharmacology Laboratory (Dr de Miranda, Dr Mauro Martins Teixeira, Dr Antônio Lúcio Teixeira), UFMG, Belo Horizonte, Brazil.
出版信息
J Occup Environ Med. 2016 Mar;58(3):272-6. doi: 10.1097/JOM.0000000000000606.
OBJECTIVES
The aim of the study was to evaluate the plasma levels of inflammatory mediators in subjects exposed to silica, with and without silicosis compared with unexposed control group; and to check the association between inflammatory mediators with pulmonary function, quality of life, functional capacity, and dyspnea grade.
METHODS
Inflammatory mediators were measured by enzyme-linked immunosorbent assay. There were 30 subjects exposed to silica and 24 control group.
RESULTS
Interleukin-6 plasma levels were higher in subjects exposed to silica with and without silicosis than in the control group. There was a positive correlation between radiological severity and the quality of life, whereas there was a negative correlation between radiological severity and pulmonary function. A negative correlation between sTNFR1 plasma level and functional capacity was found. Interleukin-10 was negatively correlated with the quality of life total score and was positively correlated with the functional capacity and pulmonary function.
目的
本研究旨在评估接触二氧化硅的受试者（有矽肺和无矽肺）与未接触的对照组相比的炎症介质血浆水平；并检查炎症介质与肺功能、生活质量、功能能力和呼吸困难分级之间的关联。
方法
通过酶联免疫吸附测定法测量炎症介质。有30名接触二氧化硅的受试者和24名对照组。
结果
有矽肺和无矽肺的接触二氧化硅受试者的白细胞介素-6血浆水平高于对照组。放射学严重程度与生活质量呈正相关，而放射学严重程度与肺功能呈负相关。发现可溶性肿瘤坏死因子受体1（sTNFR1）血浆水平与功能能力呈负相关。白细胞介素-10与生活质量总分呈负相关，与功能能力和肺功能呈正相关。
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