Li Xue, Sun Nianzheng, Huang Xiaoyang, Ju Xiuli
Department of Pediatrics, Qilu Hospital, Shandong University, Shandong, Ji'nan, P.R. China.
J Pediatr Hematol Oncol. 2014 Jul;36(5):e299-303. doi: 10.1097/MPH.0000000000000098.
The occurrence of leukemia in twins is rare but has a crucial implication in the genetic research of leukemia. This report presents 2 pairs of monozygotic twins with precursor B-cell acute lymphoblastic leukemia. Mixed lineage leukemia (MLL)-AF4 fusion genes were found in the twin sisters. This study is the first to report on infant ALL harboring the 46,XY, -4, +10, -13, del(14)(q24), -15, +2mar[4 cells] complex chromosome abnormality. Our report showed that the unified cytogenetic features in monozygotic twins and MLL-AF4 fusion gene may be necessary but insufficient for the clinical development and prognosis of identical twins with leukemia.
双胞胎患白血病的情况罕见，但对白血病的基因研究具有关键意义。本报告介绍了2对患有前体B细胞急性淋巴细胞白血病的同卵双胞胎。在这对双胞胎姐妹中发现了混合谱系白血病（MLL）-AF4融合基因。本研究首次报道了患有46,XY, -4, +10, -13, del(14)(q24), -15, +2mar[4细胞]复杂染色体异常的婴儿急性淋巴细胞白血病。我们的报告表明，同卵双胞胎中统一的细胞遗传学特征和MLL-AF4融合基因对于白血病同卵双胞胎的临床发展和预后可能是必要的，但并不充分。
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