人副流感病毒2型在小鼠L929细胞中的不完全复制。
Incomplete replication of human parainfluenza virus type 2 in mouse L929 cells.
作者信息
Ito Y, Tsurudome M, Bando H, Komada H, Nishio M
机构信息
Department of Microbiology, Mie University School of Medicine, Japan.
出版信息
Arch Virol. 1989;108(1-2):137-44. doi: 10.1007/BF01313751.
Human parainfluenza virus type 2 (HPIV-2) was tested for its ability to replicate in murine L929 cells. L929 cells were non-permissive for replication of HPIV-2. Interferon produced endogenously played no role in its incomplete replication. The mechanism by which growth of HPIV-2 was suppressed in L929 cells was studied. Synthesis of virus-specific polypeptides, particularly glycoprotein(s), was suppressed in HPIV-2-infected L929 cells. The HN mRNA could scarcely be detected in virus-infected L929 cells.
对人副流感病毒2型（HPIV - 2）在小鼠L929细胞中的复制能力进行了检测。L929细胞不支持HPIV - 2的复制。内源性产生的干扰素在其不完全复制过程中不起作用。研究了L929细胞中HPIV - 2生长受到抑制的机制。在感染HPIV - 2的L929细胞中，病毒特异性多肽，特别是糖蛋白的合成受到抑制。在病毒感染的L929细胞中几乎检测不到HN mRNA。
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