Nakhjavani Manoochehr, Ghaemi Fatemeh, Ravaghi Hamid, Aghighi Mohammad, Ghaemi Farahnaz
Department of Endoctrinology, Tehran University of Medical Sciences, Vali'asr Hospital, Tehran, Iran.
Ministry of Health and Medical Education, Tehran University of Medical Sciences, Tehran, Iran.
Urol J. 2014 May 6;11(2):1474-7.
Our aim was to evaluate short term survival rates in renal transplant recipients from deceased donors, while focusing on recipients with diabetes mellitus background.
This is a longitudinal follow-up study based on national registry of recipients in Ministry of Health and Medical Education in Iran from 2010-11. Five hundred fifty-five recipients, 226 (40.8%) females and 328 (59.2%) males, were included in the study. Mean (± SD) age of the recipients was 39 ± 14 years. Of donors 18.4% were females and 81.6% were males. Age of the donors was 33 ± 14 years. All allograft recipients from deceased donors enrolled in the study. Short-term graft survival (1 year) was determined. Data regarding age, gender, background disease and cold ischemic time of recipients and donors were collected from the organ procurement units.
Allografts were functioning in 499 (90.1%) of recipients after one year. Of recipients 38 (6.9%) died and rejection of transplanted kidney occurred in 17 (3.1%) cases. So, in 55 (9.9%) cases, allografts were not functioning. There were significant relationships between short term graft survival of donors' gender, age of recipients, cold ischemic time and level of clearance of creatinine of recipients.
In addition to cold ischemic time, graft survival can be affected by recipients' age. There are some other considerations and implications regarding the short term graft survival in renal transplantation from cadaver donors which are discussed in this paper.
我们的目的是评估来自已故供体的肾移植受者的短期生存率，同时关注有糖尿病背景的受者。
这是一项基于伊朗卫生和医学教育部全国受者登记处的纵向随访研究，时间跨度为2010 - 2011年。555名受者纳入研究，其中女性226名（40.8%），男性328名（59.2%）。受者的平均（±标准差）年龄为39±14岁。供体中18.4%为女性，81.6%为男性。供体年龄为33±14岁。所有来自已故供体的同种异体移植受者均纳入研究。确定短期移植肾存活（1年）情况。从器官获取单位收集受者和供体的年龄、性别、基础疾病以及冷缺血时间等数据。
一年后，499名（90.1%）受者的移植肾仍在发挥功能。38名（6.9%）受者死亡，17例（3.1%）发生移植肾排斥反应。因此，55例（9.9%）移植肾未发挥功能。供体性别、受者年龄、冷缺血时间以及受者肌酐清除水平与短期移植肾存活之间存在显著关系。
除冷缺血时间外，移植肾存活还可能受受者年龄影响。本文还讨论了关于尸体供肾肾移植短期移植肾存活的其他一些考虑因素和影响。
