Brock D J
Human Genetics Unit, University of Edinburgh, Western General Hospital, UK.
Clin Genet. 1989 Nov;36(5):339-47. doi: 10.1111/j.1399-0004.1989.tb03211.x.
The value of maternal periconceptional vitamin supplementation in preventing the conception of fetuses with neural tube defects has yet to be assessed in a properly designed study. Avoidance of the birth of affected infants continues to rest on second-trimester maternal serum alphafetoprotein screening. The performance of screening programmes in achieving this objective is reviewed.
