将空气/氧气泡注入兔眼前房以治疗镰状细胞病患者的前房积血。
The injection of air/oxygen bubble into the anterior chamber of rabbits as a treatment for hyphema in patients with sickle cell disease.
作者信息
Ayintap Emre, Keskin Uğurcan, Sadigov Fariz, Coskun Mesut, Ilhan Nilufer, Motor Sedat, Semiz Hilal, Parlakfikirer Nihan
机构信息
Department of Ophthalmology, Bezmialem Vakif University, 34093 Istanbul, Turkey.
Department of Ophthalmology, Mustafa Kemal University, 31000 Hatay, Turkey.
出版信息
J Ophthalmol. 2014;2014:696302. doi: 10.1155/2014/696302. Epub 2014 Apr 7.
Purpose. To investigate the changes of partial oxygen pressure (PaO2) in aqueous humour after injecting air or oxygen bubble into the anterior chamber in sickle cell hyphema. Methods. Blood samples were taken from the same patient with sickle cell disease. Thirty-two rabbits were divided into 4 groups. In group 1 (n = 8), there was no injection. Only blood injection constituted group 2 (n = 8), both blood and air bubble injection constituted group 3 (n = 8), and both blood and oxygen bubble injection constituted group 4 (n = 8). Results. The PaO2 in the aqueous humour after 10 hours from the injections was 78.45 ± 9.9 mmHg (Mean ± SD) for group 1, 73.97 ± 8.86 mmHg for group 2, 123.35 ± 13.6 mmHg for group 3, and 306.47 ± 16.5 mmHg for group 4. There was statistically significant difference between group 1 and group 2, when compared with group 3 and group 4. Conclusions. PaO2 in aqueous humour was increased after injecting air or oxygen bubble into the anterior chamber. We offer to leave an air bubble in the anterior chamber of patients with sickle cell hemoglobinopathies and hyphema undergoing an anterior chamber washout.
目的。研究镰状细胞性前房积血患者前房注入空气或氧气泡后房水部分氧分压（PaO2）的变化。方法。从同一位镰状细胞病患者采集血样。32只兔子分为4组。第1组（n = 8）未进行注射。仅注入血液为第2组（n = 8），注入血液和空气泡为第3组（n = 8），注入血液和氧气泡为第4组（n = 8）。结果。注射后10小时，第1组房水中的PaO2为78.45 ± 9.9 mmHg（均值±标准差），第2组为73.97 ± 8.86 mmHg，第3组为123.35 ± 13.6 mmHg，第4组为306.47 ± 16.5 mmHg。与第3组和第4组相比，第1组和第2组之间存在统计学显著差异。结论。前房注入空气或氧气泡后房水中的PaO2升高。我们建议在进行前房冲洗的镰状细胞血红蛋白病和前房积血患者的前房留置一个气泡。
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