Mohyl'nyts'ka L A
Fiziol Zh (1994). 2014;60(1):84-90.
Endothelial dysfunction is implicated in the pathogenesis of macrovascular complications of diabetes and atherosclerosis. Endothelial monocyte-activating polypeptide-II (EMAP-II) is a multifunctional polypeptide with proinflammatory and antiangiogenic activity. The aim of this study was to investigate the serum level of EMAP-II in obese and nonobese patients with type 2 diabetes. We found an increase of serum level of EMAP-II in obese diabetic patients compared to obese subjects without diabetes. Similar alterations were observed also in non-obese diabetic patients compared to control subjects. Moreover, it was significant elevation of serum EMAP-II in obese patients without diabetes compared to control subjects. In obese and non-obese patients with diabetes it was a significant correlation between HbAc1, blood glucose, body mass index and levels of EMAP-II, total cholesterol, LDL, HDL, triglycerides and EMAP-II. In obese non-diabetic patients it was significant correlation between BMI, triglycerides, total cholesterol and EMAP-II. The revealed change of EMAP-II serum level reflects an endothelial dysfunction in patients with type 2 diabetes. Hyperglycemia, dyslipidemia and obesity appear to be significant factors contributing to elevation of EMAP-II level.
内皮功能障碍与糖尿病和动脉粥样硬化的大血管并发症发病机制有关。内皮单核细胞激活多肽-II（EMAP-II）是一种具有促炎和抗血管生成活性的多功能多肽。本研究旨在调查肥胖和非肥胖2型糖尿病患者的血清EMAP-II水平。我们发现，与无糖尿病的肥胖受试者相比，肥胖糖尿病患者的血清EMAP-II水平升高。与对照组相比，非肥胖糖尿病患者也观察到类似变化。此外，与对照组相比，无糖尿病的肥胖患者血清EMAP-II显著升高。在肥胖和非肥胖糖尿病患者中，糖化血红蛋白、血糖、体重指数与EMAP-II、总胆固醇、低密度脂蛋白、高密度脂蛋白、甘油三酯和EMAP-II水平之间存在显著相关性。在肥胖非糖尿病患者中，体重指数、甘油三酯、总胆固醇与EMAP-II之间存在显著相关性。所揭示的EMAP-II血清水平变化反映了2型糖尿病患者的内皮功能障碍。高血糖、血脂异常和肥胖似乎是导致EMAP-II水平升高的重要因素。
