棕色脂肪组织（BAT）介导的产热的负调节因子。
Negative regulators of brown adipose tissue (BAT)-mediated thermogenesis.
机构信息
Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia.
出版信息
J Cell Physiol. 2014 Dec;229(12):1901-7. doi: 10.1002/jcp.24664.
Abstract
Brown adipose tissue (BAT) is specialized for energy expenditure, a process called adaptive thermogenesis. PET-CT scans recently demonstrated the existence of metabolically active BAT in adult humans, which revitalized our interest in BAT. Increasing the amount and/or activity of BAT holds tremendous promise for the treatment of obesity and its associated diseases. PGC1α is the master regulator of UCP1-mediated thermogenesis in BAT. A number of proteins have been identified to influence thermogenesis either positively or negatively through regulating the expression or transcriptional activity of PGC1α. Therefore, BAT activation can be achieved by either inducing the expression of positive regulators of PGC1α or by inhibiting the repressors of the PGC1α/UCP1 pathway. Here, we review the most important negative regulators of PGC1α/UCP1 signaling and their mechanism of action in BAT-mediated thermogenesis.
摘要
棕色脂肪组织（BAT）专门用于能量消耗，这一过程称为适应性产热。最近的 PET-CT 扫描显示，成年人体内存在代谢活跃的 BAT，这重新激发了我们对 BAT 的兴趣。增加 BAT 的数量和/或活性，对于肥胖及其相关疾病的治疗具有巨大的潜力。PGC1α 是 BAT 中 UCP1 介导产热的主调节因子。已经确定了许多蛋白质可以通过调节 PGC1α 的表达或转录活性来正向或负向影响产热。因此，BAT 的激活可以通过诱导 PGC1α 的正调节剂的表达或抑制 PGC1α/UCP1 途径的抑制剂来实现。在这里，我们综述了 PGC1α/UCP1 信号的最重要的负性调节因子及其在 BAT 介导的产热中的作用机制。
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