Maluenda Gabriel, Dvir Danny
Cardiovascular Center, Hospital San Borja Arriaran, School of Medicine, University of Chile, Santiago, Chile.
Expert Rev Cardiovasc Ther. 2014 Jun;12(6):693-702. doi: 10.1586/14779072.2014.916615. Epub 2014 May 9.
Transcatheter aortic valve replacement (TAVR) has emerged as an accepted indication for non-operable patients with severe symptomatic native aortic valve stenosis (AS) and as a reasonable alternative for high-risk surgical AS patients. Nonetheless, the safety and efficacy of performing TAVR in several other potential indications are yet unclear. In the present manuscript the authors review the current evidence supporting TAVR for other potential indications than the typical high-risk/non-operable AS patients, providing updated results of the main clinical trials and registries exploring these particular indications. Finally, the authors provide practical recommendations for TAVR in each of these conditions.
经导管主动脉瓣置换术（TAVR）已成为有症状的重度原发性主动脉瓣狭窄（AS）不可手术患者的公认适应症，也是高危外科AS患者的合理替代方案。尽管如此，在其他一些潜在适应症中进行TAVR的安全性和有效性仍不明确。在本手稿中，作者回顾了支持TAVR用于典型高危/不可手术AS患者以外的其他潜在适应症的现有证据，提供了探索这些特定适应症的主要临床试验和注册研究的最新结果。最后，作者针对这些情况下的TAVR提供了实用建议。
