Bikbova Guzel, Oshitari Toshiyuki, Baba Takayuki, Yamamoto Shuichi
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Chiba, Japan.
Curr Diabetes Rev. 2014 May;10(3):166-76. doi: 10.2174/1573399810666140508121927.
Diabetes mellitus is a disease with a devastating impact on population. Recent data revealed that early retinal neuropathy in patients with diabetic retinopathy involved a reduced expression of brain-derived neurotrophic factor. Retinal ganglion cells (RGC) neuropathy is a progressive optic nerve neuropathy with RGC death and axonal degeneration, and it leads to blindness in the elderly population worldwide. Thus, neuroprotective therapies that rescue damaged RGCs and inhibit the progression of RGC loss and axonal degeneration are needed. This review introduces potential neuroprotective therapies using different neurotrophic factors for damaged RGC in eyes with RGC neuropathy associated diseases.
糖尿病是一种对人群具有毁灭性影响的疾病。最近的数据显示，糖尿病视网膜病变患者的早期视网膜神经病变涉及脑源性神经营养因子表达降低。视网膜神经节细胞（RGC）神经病变是一种进行性视神经病变，伴有RGC死亡和轴突退变，它导致全球老年人群失明。因此，需要能够挽救受损RGC并抑制RGC丢失和轴突退变进展的神经保护疗法。本综述介绍了使用不同神经营养因子对患有RGC神经病变相关疾病的眼睛中受损RGC进行潜在神经保护治疗的方法。
