Shapira Yuval, Hadelsberg Uri P, Kanner Andrew A, Ram Zvi, Roth Jonathan
Department of Neurosurgery, Tel Aviv Medical Center, Tel Aviv University School of Medicine, 6 Weizman Street, Tel Aviv, 64239, Israel.
Acta Neurochir (Wien). 2014 Aug;156(8):1469-74. doi: 10.1007/s00701-014-2108-7. Epub 2014 May 9.
Brain metastases (BM) are the most common intracranial tumours amongst adults. Ten to 40 % of patients with cancer will develop BM. In this study, we observed a high affinity of renal cell carcinoma (RCC) to the ventricular system, with close association to the choroid plexus.
This is a retrospective study evaluating data of our prospectively maintained brain tumour database, focusing on consecutive BM patients, who were treated at our center between March 2003 and December 2011. Data collected included primary pathologies, anatomical distribution of the brain metastasis according to neuroimaging, and treatment modalities.
We identified 614 patients with BM, of whom 24 (3.9 %) were diagnosed with RCC, harboring 33 lesions. Nine of the 24 patients (37.5 %) presented with an intraventricular location (10 of 33 RCC BM lesions). Of the remaining 590 patients with non-RCC pathologies, five patients (0.8 %) were diagnosed with intraventricular lesions (p < 0.0001).
In this unselected, consecutive treated BM patient cohort we observed a high affinity of RCC BM to the ventricular system with close association to the choroid plexus. The reason for this affinity is unknown. Surgical approaches for resection of these lesions should be planned to include early control on the vascular supply from the choroidal vessels.
脑转移瘤（BM）是成人中最常见的颅内肿瘤。10%至40%的癌症患者会发生脑转移瘤。在本研究中，我们观察到肾细胞癌（RCC）对脑室系统具有高度亲和力，且与脉络丛密切相关。
这是一项回顾性研究，评估我们前瞻性维护的脑肿瘤数据库的数据，重点关注2003年3月至2011年12月在我们中心接受治疗的连续性脑转移瘤患者。收集的数据包括原发病理、根据神经影像学的脑转移瘤解剖分布以及治疗方式。
我们确定了614例脑转移瘤患者，其中24例（3.9%）被诊断为肾细胞癌，共有33个病灶。24例患者中有9例（37.5%）表现为脑室内占位（33个肾细胞癌脑转移瘤病灶中的10个）。在其余590例非肾细胞癌病理患者中，5例（0.8%）被诊断为脑室内病灶（p < 0.0001）。
在这个未经选择、连续治疗的脑转移瘤患者队列中，我们观察到肾细胞癌脑转移瘤对脑室系统具有高度亲和力，且与脉络丛密切相关。这种亲和力的原因尚不清楚。切除这些病灶的手术方法应计划包括早期控制脉络丛血管的血供。
