窄带成像（NBI）与自发荧光支气管镜检查（AFB）联合用于评估中央型肺癌

[Combination of narrow band imaging (NBI) and autofluorescence bronchoscopy (AFB) in the assessment of central lung cancer].

作者信息

Chen Zhongbo, Yu Yiming, Sun Shifang, Ma Hongying, Zhang Qiaoli, Lyu Dan, Wang Bijiong, Niu Liming, Cao Chao, Ding Qunli, Deng Zaichun

机构信息

Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China.

Department of Respiratory Medicine, Affiliated Hospital of Ningbo University Medical College, Zhejiang 315020, China. Email:

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2014 Mar;37(3):184-7.

PMID:24809708

Abstract

OBJECTIVE

To assess the diagnostic value of narrow-band imaging(NBI) in the diagnosis of central lung cancer.

METHODS

Patients (n = 153) suspected of having lung cancer underwent white light bronchoscopy(WLB), NBI and autofluorescence bronchoscopy(AFB) in turn. At least 3 biopsies in each case were taken from sites visualized as lesions. The sensitivity and specificity of NBI, AFB and combination of NBI and AFB were compared.

RESULTS

There were 106 male (69.3%) and 47 female patients (30.7%). By NBI, 91 and 62 cases were positive and negative respectively. The sensitivity and specificity of NBI were 63.5% (87/137) and 75.0% (12/16) respectively. By AFB, 140 and 13 cases were positive and negative respectively. The sensitivity and specificity of AFB were 94.2% (129/137) and 87.5% (5/16) respectively. By NBI combined with AFB, 133 and 20 cases were positive and negative respectively, the sensitivity and specificity being 95.6% (131/137) and 87.5% (14/16) respectively. The difference of specificity between NBI plus AFB and AFB alone was significant (P < 0.01), but the difference of sensitivity between NBI plus AFB and AFB alone(P > 0.05) was not. The difference of specificity between NBI plus AFB and NBI alone was significant (P < 0.01), but the P value of specificity between NBI plus AFB and NBI was 0.03.

CONCLUSION

Combination of NBI and AFB could increase the specificity of lung cancer diagnosis compared to AFB alone.

摘要

目的

评估窄带成像（NBI）在中央型肺癌诊断中的价值。

方法

153例疑似肺癌患者依次接受白光支气管镜检查（WLB）、NBI和自体荧光支气管镜检查（AFB）。每例至少从可视病变部位取3块活检组织。比较NBI、AFB以及NBI与AFB联合检查的敏感性和特异性。

结果

男性106例（69.3%），女性47例（30.7%）。通过NBI检查，阳性91例，阴性62例。NBI的敏感性和特异性分别为63.5%（87/137）和75.0%（12/16）。通过AFB检查，阳性140例，阴性13例。AFB的敏感性和特异性分别为94.2%（129/137）和87.5%（5/16）。NBI联合AFB检查时，阳性133例，阴性20例，敏感性和特异性分别为95.6%（131/137）和87.5%（14/16）。NBI加AFB与单独AFB相比，特异性差异有统计学意义（P<0.01），但敏感性差异无统计学意义（P>0.05）。NBI加AFB与单独NBI相比，特异性差异有统计学意义（P<0.01），但敏感性P值为0.03。