Marques Ilza Lazarini, Nackashi John, Borgo Hilton Coimbra, Martinelli Angela Patrícia Menezes Cardoso, de Souza Luiz, Dutka Jeniffer de Cássia Rillo, Williams William N, Pegoraro-Krook Maria Inês
Cleft Palate Craniofac J. 2015 Mar;52(2):192-7. doi: 10.1597/13-161. Epub 2014 May 8.
Objective : To study the growth of children with complete unilateral cleft lip and palate (UCLP) from 2 to 10 years of age and to assess whether growth varied from that of children without UCLP (typical children). Design : Physical growth was one of the outcome measures of a National Institutes of Health-sponsored longitudinal, prospective clinical trial conducted by the University of Florida and the University of São Paulo. Setting : Hospital of Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC-USP), Bauru, Brazil. Main Outcome Measures : Height and weight were prospectively measured for 360 healthy children with UCLP who were nonsyndromic, belonged to median socioeconomic status, and received health care at HRAC-USP. To compare growth of children with UCLP to that of typical children, growth curves for UCLP were developed and compared with World Health Organization curves for 2006 and 2007, which were used as reference for typical children. Third-degree polynomials were used to explain the relationship of length and weight with age. Confidence limits of 95% were used for the mean curve using the statistic Z ~ N (0,1). Results : Children with UCLP from 2 to 10 years old presented height and weight growth curves similar to those of typical children for both genders. Conclusion : Children with UCLP from 2 to 10 years old presented physical growth similar to that of typical children.
研究单侧完全性唇腭裂（UCLP）患儿2至10岁期间的生长情况，并评估其生长是否与非UCLP患儿（正常儿童）不同。设计：身体生长是由美国国立卫生研究院赞助、佛罗里达大学和圣保罗大学进行的一项纵向、前瞻性临床试验的结果指标之一。地点：巴西圣保罗大学颅面畸形康复医院（HRAC-USP），包鲁市。主要结果指标：对360名非综合征性、社会经济地位处于中等水平且在HRAC-USP接受医疗保健的健康UCLP患儿进行前瞻性身高和体重测量。为了将UCLP患儿的生长情况与正常儿童进行比较，绘制了UCLP患儿的生长曲线，并与2006年和2007年世界卫生组织的曲线进行比较，后者用作正常儿童的参考标准。使用三次多项式来解释身高和体重与年龄的关系。使用统计量Z~N(0,1)计算平均曲线的95%置信区间。结果：2至10岁的UCLP患儿无论男女，其身高和体重生长曲线均与正常儿童相似。结论：2至10岁的UCLP患儿身体生长情况与正常儿童相似。
