Villani Giovanni
Istituto di Chimica dei Composti OrganoMetallici, ICCOM-UOS Pisa Area della Ricerca del CNR, Via G. Moruzzi, 1, I-56124 Pisa, Italy.
J Phys Chem B. 2014 May 22;118(20):5439-52. doi: 10.1021/jp502792r. Epub 2014 May 9.
Four different complexes of two base pairs, an adenine-thymine and a guanine-cytosine one, have been studied in order to understand the modifications induced by the staking interaction between the two base pairs on the hydrogen atoms transfers between the bases in either base pair. The inclusion of these two kinds of interactions allows us to clarify if some properties, as the mechanism of hydrogen transfer, is exclusively a local effect of a base pair or can be modified by a more long-range interaction between the base pairs. The results on these four complexes are compared with those of the monomeric systems, the A-T and G-C base pair, and with those of the A-T and G-C dimers. The specificity of each complex and of each hydrogen bond has been analyzed.
为了理解两个碱基对（一个腺嘌呤 - 胸腺嘧啶对和一个鸟嘌呤 - 胞嘧啶对）之间的堆积相互作用对任一碱基对中碱基间氢原子转移所诱导的修饰，研究了四种不同的两个碱基对的复合物。包含这两种相互作用使我们能够阐明某些性质，如氢转移机制，是碱基对的局部效应，还是会受到碱基对之间更远距离相互作用的影响。将这四种复合物的结果与单体系统（A - T和G - C碱基对）以及A - T和G - C二聚体的结果进行了比较。分析了每种复合物和每个氢键的特异性。
