Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Institute of Biochemistry II, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Cell. 2014 May 8;157(4):767-9. doi: 10.1016/j.cell.2014.04.026.
The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.
后期促进复合物/周期蛋白体通过催化不同连接类型的同种泛素链来靶向蛋白质进行降解。在本期《细胞》中，Meyer 和 Rape 通过证明 APC/C 及其同源 E2 连接酶通过用支链 Lys11 和 Lys48 泛素链对其进行修饰，来提高底物降解的速度，从而使降解信号多样化。
