肝脏色氨酸吡咯酶。酒精偏好型C57BL小鼠大脑中5-羟色胺浓度降低的一个主要决定因素。
Liver tryptophan pyrrolase. A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice.
作者信息
Badawy A A, Morgan C J, Lane J, Dhaliwal K, Bradley D M
机构信息
Biomedical Research Laboratory, Whitchurch Hospital, Cardiff, Wales, U.K.
出版信息
Biochem J. 1989 Dec 1;264(2):597-9. doi: 10.1042/bj2640597.
Abstract
The lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL, compared with -non-preferring CBA, mice is caused by a decrease in circulating tryptophan availability to the brain secondarily to a higher liver tryptophan pyrrolase activity associated with a higher circulating corticosterone concentration. Activity or expression of liver tryptophan pyrrolase and/or their induction by glucocorticoids may be important biological determinants of predisposition to alcohol consumption.
摘要
与非嗜酒的CBA小鼠相比，嗜酒的C57BL小鼠大脑中5-羟色胺浓度较低，这是由于肝脏色氨酸吡咯酶活性较高，导致循环皮质酮浓度升高，进而使大脑可利用的循环色氨酸减少所致。肝脏色氨酸吡咯酶的活性或表达，和/或它们被糖皮质激素诱导，可能是饮酒易感性的重要生物学决定因素。
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