将大鼠肝脏色氨酸吡咯酶对血红素的利用作为药物加重肝卟啉症的筛查试验。
Heme utilization by rat liver tryptophan pyrrolase as a screening test for exacerbation of hepatic porphyrias by drugs.
作者信息
Badawy A A
出版信息
J Pharmacol Methods. 1981 Sep;6(2):77-85. doi: 10.1016/0160-5402(81)90030-9.
Rat liver tryptophan pyrrolase plays a versatile and unique role among hepatic hemoproteins in relation to heme utilization. The depletion of pyrrolase heme in the experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine is potentiated by joint administration of any one of 19 drugs known to exacerbate the human disease, but not by any of 13 nonexacerbators. These findings form the basis of a screening test for drug exacerbation of hepatic porphyrias; the conditions, details, and requirements of which are described.
大鼠肝脏色氨酸吡咯酶在肝脏血红素蛋白中，就血红素利用而言发挥着多方面且独特的作用。由3,5 - 二乙氧羰基 - 1,4 - 二氢可力丁所引发的实验性卟啉症中，吡咯酶血红素的耗竭会因联合使用已知会加重人类该疾病的19种药物中的任何一种而加剧，但不会因13种非加剧药物中的任何一种而加剧。这些发现构成了一项针对肝脏卟啉症药物加剧作用的筛查试验的基础；文中描述了该试验的条件、细节及要求。
Zotero 插件