Wang Y, Wei D, Li W, Qiu J
Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, PR China; School of Psychology, Southwest University, Chongqing 400715, PR China.
Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, PR China; School of Psychology, Southwest University, Chongqing 400715, PR China.
Neuroscience. 2014 Jul 11;272:217-28. doi: 10.1016/j.neuroscience.2014.04.045. Epub 2014 May 9.
Type A behavior pattern (TABP) is characterized by competitiveness and hostility, time urgency and impatience. These traits can have a significant impact on physical and mental health. We have not found studies focusing on brain structure or functional connectivity correlates associated with individual differences in TABP. The present study used voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analysis to examine the neural correlates of TABP. The results showed that TABP was positively correlated with regional gray matter volume (rGMV) in the left subgenual anterior cingulate cortex (sgACC), which might reflect immature functioning of this region related to impatience. In addition, TABP was positively correlated with the strength of rsFC between the left ventral striatum and areas in the left ventromedial prefrontal cortex (vmPFC) and the right rostral anterior cingulate cortex (rACC). These regions are associated with achievement striving related to impatience, aggressiveness, and worry under time pressure. In summary, the combination of morphometric results (increased rGMV of the left sgACC) and functional connectivity findings (increased rsFC between the left ventral caudate and the left vmPFC/right rACC in the fronto-striatal network) may provide a valuable basis for a comprehensive understanding of the neural circuitry underlying individual differences in TABP.
A型行为模式（TABP）的特征是竞争性和敌意、时间紧迫感和不耐烦。这些特质会对身心健康产生重大影响。我们尚未发现有研究聚焦于与TABP个体差异相关的脑结构或功能连接相关性。本研究采用基于体素的形态学测量（VBM）和静息态功能连接（rsFC）分析来检验TABP的神经相关性。结果显示，TABP与左侧膝下前扣带回皮质（sgACC）的局部灰质体积（rGMV）呈正相关，这可能反映了该区域与不耐烦相关的功能不成熟。此外，TABP与左侧腹侧纹状体和左侧腹内侧前额叶皮质（vmPFC）及右侧喙部前扣带回皮质（rACC）区域之间的rsFC强度呈正相关。这些区域与在时间压力下与不耐烦、攻击性和担忧相关的成就追求有关。总之，形态学测量结果（左侧sgACC的rGMV增加）和功能连接结果（额纹状体网络中左侧腹侧尾状核与左侧vmPFC/右侧rACC之间的rsFC增加）的结合，可能为全面理解TABP个体差异背后的神经回路提供有价值的基础。
