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以色列贝都因人近亲结婚的患病率及相关因素

Prevalence of consanguineous marriages and associated factors among Israeli Bedouins.

作者信息

Na'amnih Wasef, Romano-Zelekha Orly, Kabaha Ahmed, Rubin Liza Pollack, Bilenko Natalya, Jaber Lutfi, Honovich Mira, Shohat Tamy

机构信息

Israel Center for Disease Control, Ministry of Health, Gertner Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel,

出版信息

J Community Genet. 2014 Oct;5(4):395-8. doi: 10.1007/s12687-014-0188-y. Epub 2014 May 10.

Abstract

The Bedouin population in Israel is a semi-nomadic traditional patriarchal society. Consanguineous marriages are very common, contributing to high rates of congenital malformations and genetic diseases, resulting in high infant mortality. Data on consanguineous marriages among Bedouins in Israel are limited. This study examined the current prevalence of consanguineous marriages and their determinants among Israeli Bedouins. One thousand two hundred ninety Bedouin women who delivered in the maternity wards of the only hospital serving the Bedouin population were interviewed between November 2009 and January 2010. The prevalence of consanguineous marriages was 44.8 %. The most common type of spousal relationship was first cousins (65.7 % of all consanguineous marriages). The mean inbreeding coefficient was 0.0238. Factors significantly associated with consanguinity were less years of schooling (OR 0.94, 95 % CI (0.88-0.99), p = 0.02) and younger age at marriage of the wife (OR 0.90, 95 % CI (0.80-0.96), p = 0.0002). In conclusion, the rate of consanguineous marriages among Bedouins is very high, making this population at risk for congenital malformations and genetic diseases. Efforts should be directed at better education and provision of premarital and prenatal counseling on the health consequences of consanguineous marriages and the possibilities to lower those risks.

摘要

以色列的贝都因人群体是一个半游牧的传统父权制社会。近亲结婚非常普遍,导致先天性畸形和遗传疾病的高发病率,进而造成婴儿死亡率居高不下。关于以色列贝都因人近亲结婚的数据有限。本研究调查了以色列贝都因人中近亲结婚的当前流行情况及其决定因素。在2009年11月至2010年1月期间,对在为贝都因人群体服务的唯一一家医院产科病房分娩的1290名贝都因妇女进行了访谈。近亲结婚的流行率为44.8%。最常见的配偶关系类型是表亲(占所有近亲结婚的65.7%)。平均近亲系数为0.0238。与近亲结婚显著相关的因素是受教育年限较少(比值比0.94,95%可信区间(0.88 - 0.99),p = 0.02)以及妻子结婚时年龄较小(比值比0.90,95%可信区间(0.80 - 0.96),p = 0.0002)。总之,贝都因人中近亲结婚的比例非常高,这使得该人群面临先天性畸形和遗传疾病的风险。应致力于提供更好的教育,并就近亲结婚对健康的影响以及降低这些风险的可能性提供婚前和产前咨询。

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本文引用的文献

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