Lago M A, Rodríguez-Bernaldo de Quirós A, Sendón R, Bustos J, Santillana M I, Paseiro P
Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Anal Bioanal Chem. 2014 Jul;406(17):4251-9. doi: 10.1007/s00216-014-7792-x. Epub 2014 May 11.
Photoinitiators (PIs) are components of UV-cured inks widely used in printing of food packaging. These substances can migrate into food and may be a hazard to human health. High-performance liquid chromatography with diode-array detection (HPLC-DAD) has been used for analysis of PIs and amine synergists in food packaging. Analysis was performed with a Kromasil C18 column (250 mm × 3.2 mm i.d., 5 μm particle size) with a binary mobile phase gradient prepared from acetonitrile and Milli-Q water. The flow rate was 0.5 mL min(-1). The method enables separation of fourteen PIs and amine synergists in a single run. The method was validated for linearity, repeatability, and limits of detection and quantification. Excellent sensitivity (LODs ≤ 1.56 μg dm(2)) and appropriate repeatability (RSD (n = 10) <0.9%) were achieved. Different types of food packaging material including plastic films, cardboard, and cans were analyzed and PIs were detected in 47% of the samples tested (n = 17). Positive samples were confirmed by use of LC-MS-MS in positive electrospray ionization (ESI) mode.
光引发剂（PIs）是广泛用于食品包装印刷的紫外光固化油墨的成分。这些物质会迁移到食品中，可能对人体健康构成危害。高效液相色谱-二极管阵列检测法（HPLC-DAD）已用于分析食品包装中的光引发剂和胺增效剂。分析使用Kromasil C18柱（250 mm×3.2 mm内径，5μm粒径），以乙腈和超纯水配制二元流动相梯度。流速为0.5 mL min⁻¹。该方法能够在一次运行中分离出14种光引发剂和胺增效剂。该方法在线性、重复性以及检测限和定量限方面得到了验证。实现了出色的灵敏度（检测限≤1.56 μg dm⁻²）和适当的重复性（相对标准偏差（n = 10）<0.9%）。对包括塑料薄膜、纸板和罐头在内的不同类型食品包装材料进行了分析，在所测试的47%的样品（n = 17）中检测到了光引发剂。阳性样品通过在正电喷雾电离（ESI）模式下使用液相色谱-串联质谱法（LC-MS-MS）进行确认。
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