一种用于生物医学成像的多模态纳米复合材料。
A Multimodal Nanocomposite for Biomedical Imaging.
作者信息
Wu Aiguo, Paunesku Tatjana, Zhang Zhuoli, Vogt Stefan, Lai Barry, Maser Jörg, Yaghmai Vahid, Li Debiao, Omary Reed A, Woloschak Gayle E
机构信息
Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 USA ; Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, No. 519 Zhuangshi Rd. Zhenhai District, Ningbo City, Zheijang Province, 315201 P.R. China.
Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 USA ; Department of Radiology, Feinberg School of Medicine, and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611 USA.
出版信息
AIP Conf Proc. 2011 Sep 9;1365:379. doi: 10.1063/1.3625382.
A multimodal nanocomposite was designed, synthesized with super-paramagnetic core (CoFeO), noble metal corona (Au), and semiconductor shell (TiO). The sizes of core, core-corona, and core-corona-shell particles were determined by TEM. This multimodal nanocrystal showed promise as a contrast agent for two of the most widely used biomedical imaging techniques: magnetic resonance imaging (MRI) and X-ray computed tomography (CT). Finally, these nanocomposites were coated with a peptide SN-50. This led to their ready uptake by the cultured cells and targeted the nanocomposites to the pores of nuclear membrane. Inside cells, this nanocomposite retained its integrity as shown by X-ray fluorescence microscopy (XFM). Inside cells imaged by XFM we found the complex elemental signature of nanoconjugates (Ti-Co-Fe-Au) always co-registered in the 2D elemental map of the cell.
设计并合成了一种多模态纳米复合材料，其具有超顺磁性核（CoFeO）、贵金属冠层（Au）和半导体壳层（TiO）。通过透射电子显微镜（TEM）测定了核、核-冠层以及核-冠层-壳层颗粒的尺寸。这种多模态纳米晶体有望作为两种最广泛使用的生物医学成像技术——磁共振成像（MRI）和X射线计算机断层扫描（CT）的造影剂。最后，这些纳米复合材料用肽SN-50进行了包被。这使得它们易于被培养细胞摄取，并将纳米复合材料靶向至核膜孔。在细胞内部，如X射线荧光显微镜（XFM）所示，这种纳米复合材料保持了其完整性。在通过XFM成像的细胞内部，我们发现纳米缀合物（Ti-Co-Fe-Au）的复杂元素特征总是在细胞的二维元素图中共同定位。
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