Schurink Maarten, Scholten Iemcke G H, Kooi Elisabeth M W, Hulzebos Christian V, Kox Rozemarijn G, Groen Henk, Heineman Erik, Bos Arend F, Hulscher Jan B F
Department of Pediatric Surgery, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Neonatology. 2014;106(1):49-54. doi: 10.1159/000358582. Epub 2014 May 7.
Intestinal fatty acid-binding protein (I-FABP) is a promising marker for necrotizing enterocolitis (NEC). It can be measured in plasma (I-FABPp) and urine (I-FABPu). Data on the best way to measure I-FABP (in plasma or urine) and the necessity of simultaneous measurement of the urinary creatinine concentration to correct for physiological variations in urine concentration are not available. This holds also true for the reciprocal relation between I-FABPp, I-FABPu and other more conventional laboratory parameters.
To evaluate the above-mentioned correlations of I-FABP measurements in neonates with suspected NEC.
All neonates with suspected NEC were prospectively included. I-FABPp and I-FABPu were analyzed at regular intervals during the first 24 h after onset of symptoms. Correlation and agreement were assessed between these and other parameters (i.e., IL-6, WBC, platelet count, CRP, pH and lactate).
Included were 24 boys, 13 girls [median (range) GA 28 weeks (24-36), median birth weight 1,190 g (570-2,400)]. I-FABPu correlated strongly with I-FABPp (r 0.80, p < 0.001) with an adequate agreement. A very strong correlation between I-FABPu and I-FABPu/urine creatinine ratio (r 0.98, p < 0.001) existed. Correlations between I-FABPp/u and conventional parameters were moderate to strong until 8 h after onset of symptoms.
In neonates with suspected NEC, I-FABPu correlates strongly with I-FABPp, offering an opportunity to choose the most appropriate way of measuring I-FABP. Calculating urinary IFABP/creatinine ratio seems redundant. Moderately strong correlations between I-FABPu and IL-6, WBC and lactate were found.
肠道脂肪酸结合蛋白（I-FABP）是坏死性小肠结肠炎（NEC）的一个有前景的标志物。它可在血浆（I-FABPp）和尿液（I-FABPu）中检测。目前尚无关于测量I-FABP的最佳方法（血浆或尿液）以及同时测量尿肌酐浓度以校正尿液浓度生理变化的必要性的数据。I-FABPp、I-FABPu与其他更传统实验室参数之间的相互关系也是如此。
评估疑似NEC的新生儿中I-FABP测量的上述相关性。
前瞻性纳入所有疑似NEC的新生儿。在症状出现后的头24小时内定期分析I-FABPp和I-FABPu。评估这些指标与其他参数（即IL-6、白细胞、血小板计数、CRP、pH值和乳酸）之间的相关性和一致性。
纳入24名男孩、13名女孩[中位（范围）胎龄28周（24 - 36），中位出生体重1190克（570 - 2400）]。I-FABPu与I-FABPp密切相关（r = 0.80，p < 0.001），一致性良好。I-FABPu与I-FABPu/尿肌酐比值之间存在非常强的相关性（r = 0.98，p < 0.001）。症状出现后8小时内，I-FABPp/u与传统参数之间的相关性为中度至高度。
在疑似NEC的新生儿中，I-FABPu与I-FABPp密切相关，为选择测量I-FABP的最合适方法提供了机会。计算尿IFABP/肌酐比值似乎多余。发现I-FABPu与IL-6、白细胞和乳酸之间存在中度至高度相关性。
