Corr Maripat
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Clin Rheumatol. 2014 Jun;33(6):759-62. doi: 10.1007/s10067-014-2663-6. Epub 2014 May 13.
The mechanisms that lead to bony fusion in ankylosing spondylitis (AS) are yet to be fully defined. In recent years, there have been several advances in our understanding of this complex disease. Here, the potential impact of the Wnt signaling pathway will be discussed. This pathway is involved in bone morphogenesis and homeostasis. Perturbations in the normal regulation have been implicated in abnormal bone formation (e.g., osteophytes). Levels of Wnt regulatory proteins like Dickkopf have been investigated as potential biomarkers of disease. This pathway might be involved in other aspects of this disease including T cell activation and differentiation, and in bone marrow adipogenesis. The pathways leading to the unique pathology and bony fusion in AS are complex and the Wnt pathway might play a critical contributing role.
导致强直性脊柱炎（AS）骨融合的机制尚未完全明确。近年来，我们对这种复杂疾病的认识有了一些进展。在此，将讨论Wnt信号通路的潜在影响。该通路参与骨形态发生和内环境稳定。正常调节的紊乱与异常骨形成（如骨赘）有关。像Dickkopf这样的Wnt调节蛋白水平已被作为疾病的潜在生物标志物进行研究。该通路可能还参与了这种疾病的其他方面，包括T细胞活化和分化，以及骨髓脂肪生成。导致AS独特病理和骨融合的通路很复杂，Wnt通路可能起着关键的促成作用。
